Human immunodeficiency virus (HIV) is a complex condition that affects millions worldwide. While there is no cure yet, antiretroviral therapy (ART) can effectively control the virus.
Two newer ART options are Juluca and Biktarvy. But how do these treatments compare? Which one is better for different patients? This comprehensive guide examines the key features, pros and cons to consider.
Feature | Juluca | Biktarvy |
Year Approved | 2017 | 2018 |
Active Ingredients | Dolutegravir sodium, rilpivirine hydrochloride | Bictegravir sodium, emtricitabine, tenofovir alafenamide |
Administration | With 500+ calorie meal | No regard to food |
Viral Suppression | Slower, drops over time in some groups | Faster, remains higher over time |
Side Effects | Less diarrhea, nausea, headache | More GI issues, headaches |
Kidney Impact | Rare | Possible in at-risk people |
Cost | $3,118 per 30 tablets | $3,132 per 30 tablets |
Juluca and Biktarvy are both complete HIV treatment regimens containing multiple antiretroviral medications in one tablet. This approach, known as single tablet regimen (STR), makes adherence easier compared to multi-pill cocktails.
Juluca contains dolutegravir sodium and rilpivirine hydrochloride. It was approved by the FDA in 2017. Biktarvy consists of bictegravir sodium, emtricitabine, and tenofovir alafenamide. It received approval one year after Juluca in 2018.
While both are STRs, Juluca and Biktarvy have important differences in their drug composition, efficacy, side effects, and more. We’ll explore those next.
Efficacy measures how well a drug achieves its intended effect. For HIV medication, that’ssuppressing viral load and T-cell count.
Overall, Biktarvy demonstrates higher efficacy than Juluca:
So why is Biktarvy more effective? Two key reasons:
For these reasons, Biktarvy pulls ahead of Juluca for efficacy. However, Juluca still suppresses HIV well for many patients.
Medications can cause unwelcome side effects. This is a key area where Juluca shines over Biktarvy.
In head-to-head studies, Juluca had lower rates of adverse effects including:
Why does Juluca have fewer side effects? Primarily thanks to rilpivirine, which is gentler than Biktarvy’s bictegravir.
Additionally, Biktarvy contains two medications that may negatively impact kidney function in susceptible individuals. So far, clinical data shows Juluca rarely negatively affects kidney health.
Clearly, Juluca’s superior side effect profile gives it an advantage that some patients may prefer.
Also Read: Is Mounjaro Better Than Gastric Sleeve?
Juluca and Biktarvy also differ in how they interact with food and other medications:
So Biktarvy offers more convenience regarding administration. Juluca needs a little more planning around meals and other drugs to work properly.
While both treatments work for a wide range of patients, some key population differences emerge:
Assessing individual medical history helps determine which medication has preferable characteristics.
Also watch the video of Biktarvy!
In the United States, both Juluca and Biktarvy have a similar high cost:
So unfortunately neither treatment offers big cost savings over the other. Those without drug coverage can explore manufacturer payment assistance and discount programs to offset expense.
Juluca offers an alternative complete HIV regimen to Biktarvy with different drug composition and characteristics. Other options are multi-tablet treatments like Dovato, Triumeq, and Stribild.
No, Biktarvy shows higher efficacy and fewer side effects compared to Truvada in clinical studies. As Truvada only contains two HIV drugs versus Biktarvy’s three, Biktarvy works better overall.
Potentially yes – Biktarvy contains emtricitabine and tenofovir which may negatively impact kidney function in at-risk individuals like those with untreated HIV, diabetes, or hypertension. Juluca avoids this kidney risk.
Juluca – no generic forms are available yet. Juluca contains the active ingredients dolutegravir sodium and rilpivirine hydrochloride.
Also Read: Comparison Between Stasis And Thesis.
In the end, is Juluca or Biktarvy the “better” HIV treatment? The answer depends on each patient’s needs and preferences.
Biktarvy is the clear winner for efficacy thanks to its newer antiretrovirals and higher genetic resistance barrier. So patients prioritizing maximum viral suppression may fare better on Biktarvy long-term.
However, Juluca shines when side effect minimization is top priority. With lower rates of adverse effects like diarrhea, nausea, and headaches, some patients tolerate Juluca much better.
Discuss options with your doctor to determine if easy-to-take Juluca or robust Biktarvy aligns best with your health goals. Either way, both medications transform HIV into a very manageable condition for most people today.
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